LYUH ESTHER ST.JOHN’S WORT PLUS

Daily Intake: 20ml

※ % Nutritional Value: Percentages of the daily nutritional value

1. **St. John’s Wort (Hypericum perforatum)**
– Hypericin, an abundant ingredient in St. John’s wort, inhibits the serotonin-degrading enzyme in synapses between nerve cells.
-> Suppresses symptoms like depression and anxiety due to reduced serotonin.
– Inhibits reuptake of neurotransmitters such as serotonin, norepinephrine, dopamine, GABA, L-glutamate, among others.
– Regulates cortisol levels in the hypothalamus-pituitary-adrenal axis, associated with depression, anxiety, fatigue, and insomnia.
– St. John’s Wort’s effects recorded in SCI/SCIE-level academic journals
Reduced sleep disorders, increased sleep duration, and significant improvement in symptoms due to sleep deprivation.
In menopausal women receiving St. John’s Wort in combination with therapeutic drugs, menopausal symptom scores (MRS), PSYCHE sub-scores (depression, anxiety, hypersensitivity), as well as performance and memory scores improved (p < 0.001).

2. **GABA (γ-AminoButyric Acid)**
– A prominent inhibitory neurotransmitter in our central nervous system.
– An amino acid that promotes metabolic functions of brain cells and stabilizes nerves.
– When the enzyme that synthesizes GABA in brain tissue, glutamate decarboxylase, is deficient, the GABA concentration in the brain decreases, leading to a decrease in inhibitory neurotransmission.
(*Glutamate acts as an excitatory neurotransmitter, converted to GABA through the action of vitamin B6 and glutamate decarboxylase).
– Increases alpha waves in the brain, a relaxed state of brain activity, and reduces beta waves associated with stress and anxiety.
– One of GABA’s essential functions is to alleviate stress and anxiety.

3. **L-Tryptophan**
– An essential amino acid required for the synthesis of serotonin, melatonin, and vitamin B3 (niacin)
(Tryptophan -> Serotonin -> Melatonin).

4. **Tart Cherry**
– Contains a significant amount of melatonin, the circadian rhythm-regulating hormone.
– Melatonin is a biologically produced hormone secreted primarily at night and plays a role in the recovery of circadian rhythms.

1) Contains St. John’s Wort (Hypericum perforatum) extract powder, which may help with sleep and menopausal symptoms.
– Inhibits the reuptake of neurotransmitters such as serotonin, norepinephrine, dopamine, GABA, L-glutamate, among others, and regulates cortisol secretion in the hypothalamus-pituitary-adrenal axis, providing assistance in managing symptoms of depression, anxiety, fatigue, and insomnia.
– The effects of St. John’s Wort have been documented in human experiments and published in SCI/SCIE-level academic journals.

2) Includes GABA (γ-AminoButyric Acid) for better sleep health.
– Contains 1,000mg of GABA, a neurotransmitter that acts as an inhibitory neurotransmitter in the central nervous system of the body.
– Made with domestically sourced GABA ingredients that are Halal, Kosher, and non-GMO certified.
– High-purity fermented GABA produced through a patented enzymatic process: [Patent No. 10-0867215].
– GABA produced from kimchi probiotics through the supply of glutamate: [Patent No. 10-1740968].
– The effects of GABA have been recorded in SCI-level academic journals, showing that GABA intake can help alleviate tension and stress.

3) Combines various ingredients for better sleep health.
– Contains L-tryptophan, necessary for the production of melatonin, a hormone that regulates the body’s circadian rhythms.
– Contains tart cherry concentrate with a high amount of melatonin.

4) Dr. LYUH ESTHER’s expertise in ingredient blending.
– Dr. LYUH ESTHER: Preventive Medicine Ph.D. from Seoul National University College of Medicine, a specialist in Family Medicine.

Those who have recently become very nervous and have difficulty falling asleep

Those who suffer from frequent headaches due to excessive stress

Those who do not feel refreshed even after sleeping

Those who want to greet a comfortable morning

Those who have long-lasting anxiety or tension

Those who suffer from lack of sleep and rest

Workers with frequent stress

Housewives tired of childcare