DR.ESTHER LACTIUM PLUS

Casein hydrolysate (Lactium/France), dried yeast (contains selenium), maltodextrin, seasoning complex powder (L-glutamic acid, rice bran extract, dextrin, yeast extract, powdered crystalline glucose, Lactobacillus brevis /Korea), other syrups, seaweed calcium (UK), cottonseed oil powder (USA), carboxymethylcellulose calcium, dried sake yeast, L-tryptophan, milk calcium, St. John's Wort extract powder, Montmorency tart cherry powder, passionflower extract powder, corn protein extract powder
* Contains milk

Daily Intake: 2 tablets (1,600mg)

※ % Nutritional Value: Percentages of the daily nutritional value

1. Lactium (Milk Protein Hydrolysate)
- A physiologically active protein peptide created by hydrolyzing casein protein, one of the milk proteins.
- It acts on GABA receptors and has the functional claim of "helping improve sleep quality."
- It aids in nervous system stability, stress relief, and alleviating insomnia.
* Note: Milk contains protein and tryptophan, which are rich in serotonin, a neurotransmitter related to mood, and the precursor to melatonin, which is related to the body's biological clock.

2. GABA (γ-AminoButyric Acid)
- The body's primary inhibitory neurotransmitter present in the central nervous system.
- Increases the relaxed state of the brain's activity, known as alpha waves, and decreases beta waves associated with stress and anxiety.
- One of GABA's most important functions is to alleviate stress and anxiety.

3. St. John's Wort Extract Powder
- Contains an ingredient called hypericin that inhibits serotonin-degrading enzymes.
- Suppresses the secretion of stress hormones, has calming effects, and acts on receptors related to anxiety, depression, and sleep disorders.
- Also exhibits similar actions to female hormones and can be used for menopausal symptoms.

4. Evening Primrose Extract
- Contains the compound harmine, which has calming effects and induces mild euphoria. It is used as a relaxant and analgesic.

5. Tryptophan
- An essential amino acid necessary for the production of serotonin, melatonin, and vitamin B3 (niacin).
(Tryptophan -> Serotonin -> Melatonin)

6. Montmorency Tart Cherry
- Abundantly contains melatonin, a hormone responsible for regulating the biological clock.
- Melatonin is primarily secreted in the brain during the night and contributes to the recovery of the biological clock.

7. Saccharomyces cerevisiae Yeast
- A type of yeast used in the brewing of beer.
- Increases the activation of the adenosine A2A receptor, which induces deep sleep with increased delta waves, enhancing sleep quality.
- Promotes the secretion of growth hormone during sleep, which strengthens the immune system, increases muscle mass, and promotes bone formation.

1) Three different tablets are combined in one pouch for your convenience, designed to help support sleep health.

2) Tablet No. 1: Contains 300mg of casein hydrolysate (Lactium), a separately approved functional ingredient as the main ingredient
└ Alpha S1-casein (αs1-casein) (f91-100) 6.3mg

3) Tablet No. 2: Contains 55μg of selenium, which is necessary for protecting cells from harmful free radicals, as the main ingredient.
Additional ingredients include 250mg of GABA (Gamma-Aminobutyric Acid), which helps increase alpha brain waves to reduce stress and anxiety, 50mg of L-tryptophan, essential for the synthesis of neurotransmitters and neurohormones, 25mg of St. John's Wort extract powder, which aids in nerve stabilization and sleep, 25mg of Montmorency tart cherry powder, and 25mg of passionflower extract powder.

4) Individually Approved Functional Ingredient: Casein Hydrolysate (Lactium)
- Casein, a type of milk protein, is hydrolyzed with water to create bioactive protein peptides.
- Contains 300mg of casein hydrolysate (Lactium, individually approved) per daily dose, allowing for easy and low-dosage consumption.
- Functionality: May help improve sleep quality (Individual Approval Number: 2020-2).
- Uses the exclusive ingredient from Ingredia, a global dairy processing company with over 70 years of experience, based in France.
- Joint Research: Conducted in collaboration with the Sleep Center at Ewha Womans University Mokdong Hospital.
- Proven Efficacy: Lactium has been featured in over 7 SCI-level papers through years of research and development.
- Manufactured by Novarex, an R&D-focused company, using their expertise and know-how, making it the 36th individually approved functional ingredient.
- Human Application Study: A clinical study conducted with 96 participants over 4 weeks showed that taking 300mg/day of Lactium (casein hydrolysate) increased total sleep time and sleep efficiency while decreasing time taken to fall asleep and time spent awake during sleep.
  ->Sleep efficiency improved based on both subjective (sleep diaries) and objective (actigraphy) measures, with participants reporting better sleep quality.
  ** Actigraphy: A portable device worn on the wrist to measure sleep patterns.
- Safety: Lactium is a safe ingredient, registered with the FDA NDI (NDI No. 242)

5) Dr. Esther Lyuh's Ingredient Blending Expertise
- Dr. Esther Lyuh: A preventive medicine doctor with a Ph.D. from Seoul National University College of Medicine, and a specialist in family medicine.
- Developed ingredient combinations tailored to the unique constitution and health conditions of Koreans.

- Those who have recently become more sensitive and find it difficult to fall asleep 
- Those who don't feel refreshed even after sleeping 
- Those who want to wake up to a comfortable and refreshing morning 
- Those who want to focus on the quality of sleep rather than the quantity