Menopause Care Rhubarb All In One

- Relieves menopausal symptoms

- Supports hormonal balance and well-being

- Helps maintain bone health after menopause

Vitamin D3 premix (vitamin D3, dextrin, ethyl cellulose, mixed tocopherol [d-alpha-tocopherol], medium-chain triglycerides), rhubarb root extract (Germany), vitamin K1 premix (vitamin K1, gum arabic, sucrose), pyridoxine hydrochloride (vitamin B6), microcrystalline cellulose, lactose blend powder (lactose [USA], dextrin), carnauba wax, cottonseed oil powder (USA), hydrolyzed guar gum, pomegranate concentrate powder, soy isoflavones, safflower seed extract powder, red ginseng concentrate powder, cranberry concentrate powder, botanical extract powder

* Contains milk and soybean

Precautions for Consumption

- Swallow with water to avoid choking

- Discontinue use if you experience gastrointestinal discomfort or indigestion

- If any abnormal symptoms occur due to your physical condition, stop intake

- Do not consume if the product appears abnormal before intake

- Individuals with allergies to specific ingredients should check the label before use

- Infants, children, pregnant or breastfeeding women should take with caution

- Those sensitive to estrogen should use with caution

- May cause digestive discomfort or diarrhea, including nausea

- People with allergies or specific medical conditions should consult a healthcare professional before use

- Discontinue use and consult a healthcare professional if any adverse reactions occur

- Consult a healthcare professional if you have hypercalcemia or are taking medications

- Consult a healthcare professional if you are taking anticoagulants or similar medications

Daily Intake: 1 tablet (200mg)

※ % Nutritional Value: Percentages of the daily nutritional value

1. What Are Menopause and the Climacteric Period?

1-1. Menopause

- Menopause refers to the point or stage when a woman’s menstrual periods permanently stop due to a decline in ovarian function and a decrease in female hormones as she ages.

- While menopause is a natural part of aging, the issue lies in the menopausal symptoms that cause physical and psychological discomfort.

- The average age of menopause among Korean women is 49.7 years, and with an average life expectancy of 83.3 years, women typically spend about 30 years in a postmenopausal state.

1-2. Climacteric Period

- The climacteric period is a broader term than menopause and refers to the transition from a woman’s reproductive years into menopause.

- As levels of the female hormones estrogen and progesterone decline, menopausal syndrome can develop.

2. Causes and Symptoms of Menopausal Syndrome

- Cause: Triggered by a drop in estrogen levels and reduced activation of estrogen receptors in the body.

- Symptoms: Include both physical symptoms (hot flashes, limb pain, sweating, fatigue, headaches, dizziness, numbness, etc.) and psychological symptoms (anxiety, nervousness, insomnia, mood swings, depression, etc.).

- Estrogen Receptor Distribution in the Body
① Estrogen receptor-α (ER-α): uterus, bones, breasts, liver
② Estrogen receptor-β (ER-β): intestines, bone marrow, vascular endothelium, cardiovascular system
③ GPR30: adrenal medulla, renal pelvis, ovaries, brain

3. Rhubarb Root Extract for Menopausal Symptom Relief

- Rhubarb root, also known as rhei radix et rhizoma, has long been used medicinally and is commonly used in Germany for women experiencing infrequent or absent menstruation or menopausal disorders.

- Rhubarb root extract has estrogen-like activity, which may help support women's health during menopause.

- Mechanism of Action
① Activation of ER-β: Functions as a phytoestrogen, increasing ER-β activation to alleviate menopausal symptoms
② Inhibition of Oxidative Stress: By suppressing arginase activity, it promotes nitric oxide (NO) production and reduces the generation of reactive oxygen species (ROS), thereby helping to improve endothelial cell dysfunction.

- Clinical Trial Results
Participants:109 menopausal women aged 45–55 (rhubarb group: 54 | control group: 55)
112 menopausal women aged 45–55 (rhubarb group: 56 | control group: 56)

Method: Daily intake of 4 mg rhubarb root extract for 12 weeks

Results: Significant improvements in the total Menopause Rating Scale (MRS) score and 11 subcategories, Decrease in frequency of hot flashes, Improvement in Hamilton Anxiety Scale (HAMA) total score, Alleviation of both physical and psychological anxiety symptoms, Improvement in the Menopause-Specific Quality of Life (MENQOL) total score

[Sources: Menopause (New York, N.Y.) vol. 13, no. 5 (2006): 744–759; Alternative Therapies in Health and Medicine vol. 15, no. 1 (2009): 24–34.]

1. Individually Approved Functional Ingredient by MFDS: Rhubarb Root Extract (Lafontin 2.52 mg)

- Provides 100% of the daily recommended intake with just one tablet per day

- Uses a patented percolation extraction method (7 patents across Europe, U.S., Canada, Australia)
*A method that concentrates the raw material up to 2,600%

- Uses a safe, registered ingredient listed in FDA (NDI) and Canada’s NHP database

2. Main Ingredients for Menopausal Symptom Relief & Bone Health

① Rhubarb Root Extract

- Lafontin activates estrogen receptor beta (ER-β), mimicking estrogen activity

- Clinical trials confirm improvements in both physical and psychological menopausal symptoms

- Clinical trial results
4 mg/day for 4 weeks: significant improvement in Menopause Rating Scale (MRS), Hamilton Anxiety Scale (HAMA), and both physical & mental anxiety

4 mg/day for 12 weeks: improved hot flash frequency, MRS (11 subcategories), and Menopause-Specific Quality of Life (MENQOL) score

② Vitamin B6

- Elevated homocysteine levels post-menopause are linked to decreased bone density

- Vitamin B6 helps maintain normal homocysteine levels

③ Vitamin D & Vitamin K

- Estrogen deficiency after menopause accelerates bone loss and reduces bone density

- Vitamin D may help reduce the risk of osteoporosis and supports estrogen biosynthesis in the ovaries*

- Vitamin K promotes osteoblast formation and reduces osteoclast activity, supporting bone formation while reducing bone resorption

3. Plant-Based Sub-Ingredients for Menopausal Care

- Soy isoflavones, pomegranate concentrate powder, red ginseng extract powder, cranberry concentrate powder, safflower seed extract powder

* 18-type botanical blend: Eucommia bark, Korean black raspberry, kudzu root, cassia seeds, astragalus, tangerine peel, jujube, Siberian ginseng stem, deodeok, goji berry, mulberry, Solomon’s seal, dandelion, malt, Korean angelica root, yam, pine needles, ginger

4. No Artificial Additives

- Free from silicon dioxide, magnesium stearate, HPMC, carboxymethyl cellulose, synthetic flavorings, colorants, and sweeteners

5. Small Tablet Format

- One mini-tablet per day with hygienic PTP packaging for convenience

6. Manufactured Under Global Quality Standards

- Produced at COSMAX BIO, a facility certified with GMP, ISO 9001, and FSSC 22000

7) Dr. Esther Lyuh’s Formulation Expertise

- Dr. Esther Lyuh: PhD in Preventive Medicine from Seoul National University, Board-Certified in Family Medicine

- Developed with careful consideration of the nutritional status and dietary habits of Korean individuals

Recommended Target

- For women needing health support during menopause

- For those who are seeking hormone balance after menopause

- For all middle-aged women who wish to maintain health and graceful living

- For those who are looking for a thoughtful gift for a middle-aged woman

- For those who want to support physiological balance, social wellness, and marital health

- For those who want to maintain strong and healthy bones with age