| Ingredients & Contents |
Vitamin D3 mixed preparation {Vitamin D3, dextrin, ethylcellulose, d-tocopherol (mixed form), medium-chain triglycerides}, rhubarb root extract (Germany), vitamin K1 mixed preparation (Vitamin K1, arabic gum, sucrose), vitamin B6 hydrochloride, microcrystalline cellulose, lactose blend powder {lactose (USA), dextrin}, carnauba wax, cottonseed oil powder (USA), hydrolyzed guar gum, pomegranate concentrate powder, soy isoflavones, evening primrose seed extract powder (safflower seed extract powder), red ginseng concentrate powder, cranberry concentrate powder, plant mixed extract powder.
* Contains milk and soy |
| Main Ingredient |
1. What Is Menopause and Perimenopause?
1-1. Menopause
- Menopause refers to the natural cessation of normal menstrual cycles in women due to the decline in ovarian function and a decrease in female hormones as they age.
- While menopause is a natural aging process in women, the uncomfortable symptoms associated with this hormonal decline are known as perimenopausal symptoms.
- The average age of menopause in Korean women is 49.7 years, and the average lifespan for women is 83.3 years, which means that women spend approximately 30 years in a menopausal state.
1-2. Perimenopause
- Perimenopause is a broader term than menopause and refers to the transitional period when a woman transitions from her fertile years to menopause.
- During perimenopause, there is a decrease in female hormones, estrogen, and progesterone, leading to the development of perimenopausal syndrome.
2. Causes and Symptoms of Perimenopause
- Causes: Perimenopause occurs due to a decrease in the concentration of estrogen in the body and reduced activity of estrogen receptors.
- Symptoms: Perimenopausal symptoms include vasomotor symptoms (hot flashes, night sweats, palpitations, fatigue, headaches, dizziness, numbness, etc.) and psychological symptoms (anxiety, tension, insomnia, depression, etc.).
- Distribution of estrogen receptors in the body:
① Estrogen Receptor-Alpha (ER-α): Uterus, bones, breasts, liver, etc.
② Estrogen Receptor-Beta (ER-β): Intestines, bone marrow, vascular endothelium, cardiovascular system, etc.
③ GPR30: Adrenal glands, uterus, ovaries, brain, etc.
3. Improvement of Perimenopausal Syndrome with Rhubarb Root Extract
- Rhubarb root, also known as "rhubarb," has been used for its medicinal properties, particularly in Germany, for several decades to alleviate symptoms in women experiencing infrequent menstruation, amenorrhea, or perimenopausal disorders.
- Rhubarb root extract has estrogen-like activity, which can contribute to women's health during perimenopause.
- Mechanisms of action:
① Increased ER-β activity: By increasing ER-β activity through plant-based estrogen-like action, perimenopausal symptoms can be relieved.
② Suppression of reactive oxygen species (ROS) generation: By inhibiting the activity of arginase, it increases the production of nitric oxide (NO) and inhibits the generation of reactive oxygen species (ROS), improving the dysfunction of vascular endothelial cells.
- Human clinical trial results
Subjects: 109 women aged 45-55 in perimenopause (54 in the rhubarb root extract group | 55 in the control group) 112 women aged 45-55 in perimenopause (56 in the rhubarb root extract group | 56 in the control group)
Method: Participants were given 4mg/day of rhubarb root extract for 12 weeks.
Results: Improvement in the Menopause Rating Scale (MRS) total score and 11 individual items, reduction in the frequency of hot flashes, improvement in the Hamilton Anxiety Rating Scale (HAMA) total score related to depression, and improvement in physical and mental anxiety related to HAMA, as well as overall improvement in the Menopause-Specific Quality of Life (MENQOL) total score confirmed.
[Source: Menopause (New York, N.Y.) vol. 13,5 (2006): 744-759., Alternative therapies in health and medicine vol. 15,1 (2009): 24-34.]
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| Selling Point |
1) Utilizing Rhubarb Root extract individually recognized for its functionality by the Ministry of Food and Drug Safety, with a content of 2.52mg of Rhaponticin.
- Consume 100% of the daily intake of Rhubarb Root extract with just one tablet per day.
- Using a percolation extraction method that has received 7 patents in 4 countries, including Europe, the United States, Canada, and Australia, which can concentrate the extract up to 2,600% from the raw material.
- Utilizing safe ingredients registered with the US FDA NDI and Canadian NHP.
2) Primary Ingredients: A combination of ingredients designed for alleviating menopausal symptoms and promoting bone health.
① Rhubarb Root Extract
- Rhaponticin activates estrogen beta receptors (ER-β), demonstrating estrogen-like effects.
- Clinical trials have shown improvements in physical and mental menopausal symptoms with the consumption of 4mg of Rhubarb for 4 weeks, including significant enhancements in the Menopause Rating Scale (MRS) total score, the Hamilton Anxiety Rating Scale (HAMA) total score, physical discomfort, and mental discomfort. With a 12-week consumption of 4mg of Rhubarb, there were improvements in flushing frequency, the Menopause-Specific Quality of Life (MENQOL), and 11 other MRS items.
② Vitamin B6
- The increase in serum homocysteine levels after menopause is related to decreased bone density.
-Vitamin B6 is necessary to maintain normal serum homocysteine levels.
③ Vitamin D and Vitamin K
- Estrogen deficiency due to menopause accelerates bone loss and reduces bone density.
- Vitamin D can help reduce the risk of osteoporosis and promote estrogen synthesis in the ovaries.
- Vitamin K promotes the formation of bone cells, reduces bone-resorbing cells, and supports bone formation while preventing bone resorption.
3) Secondary Ingredients: A blend of various plant-derived estrogen ingredients for managing menopausal symptoms.
- Includes soy isoflavones, pomegranate concentrate powder, ginseng concentrate liquid powder, cranberry concentrate powder, hawthorn seed extract powder, and a mixture of 18 plant extracts.
- The 18-plant mixture includes Codonopsis, Rubus, Astragalus, Pueraria, Cornus officinalis, Citrus peel, Jujube, Eucommia ulmoides, Morus, Schisandra, Elaeagnus, Cornus kousa, Plantago, Wheat, Angelica sinensis, Cannabis, Pine needles, and Ginger.
4) No Additives: The product is free of additives such as silicon dioxide, magnesium stearate, HPMC, carboxymethyl cellulose, synthetic flavorings, colorings, or sweeteners.
5) Ultra-Fine Tablets: Convenient daily consumption with one mini-tablet and hygienic packaging in PTP (Press-Through-Package).
6) Manufactured in Internationally Certified Facilities: The product is manufactured under strict quality control in a globally recognized manufacturing facility with certifications including GMP, ISO 9001, and FSSC 22000.
7) Formulated by Dr. Lyuh Esther
- Dr. Lyuh Esther, a Doctor of Preventive Medicine degree from Seoul National University College of Medicine and is a specialist in Family Medicine, considering the nutritional status and diet of Koreans when developing the ingredient mix.
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