LYUH ESTHER SAC FERMENTED BLACK GARLIC DIRECT

1. SAC (S-Allyl-Cysteine) - SAC is a water-soluble sulfur compound found in garlic extract during high-temperature aging. It has garnered attention as a new active ingredient in garlic. - Garlic injection, used in dermatology for fatigue recovery, primarily contains Allicin (Allysin + Thiosin), but SAC has gained more attention due to superior research results and mechanisms compared to the older Allicin. - During the aging process of garlic extract, the Allin content decreases to 10% or less, while the SAC content increases by more than four times*1. - Various mechanisms related to [antioxidant, anti-inflammatory, vascular diseases] improvement, as well as [fatigue recovery], have been confirmed through SCIE-grade papers.

2. Human Trials on SAC's Effects ① **Antioxidant and Anti-inflammatory Activity**: SAC demonstrates antioxidant properties by removing reactive oxygen species, reducing lipid peroxidation, increasing GSH levels, activating Nrf2 factor, and reducing cytokines. ② **Fatigue Recovery (Korea FDA Biomarkers)** - **Blood**: Promotes glucose metabolism in skeletal muscles, increases lactate dehydrogenase, reduces lactate concentration, has antioxidant and anti-inflammatory effects. - **Muscles**: Increases lactate dehydrogenase activity. - **Brain**: Reduces cortisol levels, prevents dopamine depletion, decreases TGF-β (transforming growth factor beta). ③ **Vascular Health (Alleviating Hypertension and Coronary Artery Atherosclerosis)**, **Anti-Cancer (Reducing Tumor Size in Colorectal Cancer)**, **Weight Loss (Reducing Body Fat)**.

1. What is Garlic Injection? - Garlic injection is a prescribed injection used for the purpose of fatigue recovery in dermatology. Its primary component is 'Fulsultiamine.' - In the early 1990s, it was used in Japan for the purpose of enhancing the recovery and stamina of athletes*2. - Fulsultiamine is a chemically synthesized compound that increases the bioavailability of Allicin (Allysin + Thiosin) found in garlic. - Inspired by the well-recognized and effective garlic injection, SAC and thiamine were blended as ingredients, replacing Allicin.

2. Why the Brain is Vital for Chronic Fatigue Recovery - [Korea FDA] Chronic fatigue recovery is a state where fatigue persists for more than six months, even with rest, accompanied by a decrease in cognitive ability, sleep disorders, reduced concentration, and more. - Among the [blood, muscle, and brain] biomarkers related to fatigue recovery, the brain is particularly important in chronic fatigue. - According to the [North American Nursing Diagnosis Association], when defining fatigue as a "state characterized by overwhelming, sustained exhaustion not relieved by rest," it must be perceived by the 'brain.'

3. Basic Superhealth and Fatigue Recovery Effects of SAC (Anti-Inflammation, Antioxidation, Anti-Cancer, Vascular Health Improvement) - SAC is a component in fermented garlic extract that increases more than fourfold during aging and is associated with various mechanisms related to fatigue recovery. - **Anti-oxidation and Anti-inflammation Mechanisms** - Removal of Reactive Oxygen Species: Eliminates hydrogen peroxide, superoxide anion, hydroxyl radical, and peroxynitrite radicals. - Induction of Antioxidant Enzymes: Reduces lipid peroxidation, increases GSH levels. - Activation of Nrf2 Factor: Increases NAD expression and Nrf2 in the brain. *Nrf (Nuclear factor erythroid 2-related factor) regulates the basal and induced expression of antioxidant and cell-protective genes as a guardian of redox homeostasis. - Inhibition of Oxidative Enzymes: Inhibits NOS, XO, NADPH, and COX. - Reduction of Cytokines: Decreases IL-1 and TNF-α.

- **Fatigue Recovery Mechanisms** - **Blood Mechanism** - Glucose: Promotes glucose metabolism in skeletal muscles (increased SDH activity, SOD activity regulation). - Lactate: Decreases lactate concentration, increases lactate dehydrogenase. - **Muscle Mechanism** - LDH: Decreases lactate concentration, increases lactate dehydrogenase. - **Brain Mechanism** - Corticosterone: Reduces cortisol. - Dopamine: Prevents dopamine depletion. - TGF-β: Decreases transforming growth factor beta concentration. *TGF-β: Transforming growth factor beta; an increase in its concentration is known to increase fatigue and depression in the brain.

4. Vitamin B1, Vitamin B2, Vitamin B3: Synergy in Fatigue Recovery through TCA Metabolism Support - TCA metabolism is the process of cellular respiration where pyruvate, derived from glucose breakdown, is metabolized to produce energy within mitochondria. - SAC promotes glucose metabolism by increasing SDH (succinate dehydrogenase) activity in the TCA metabolism process. - Vitamin B1 helps convert alpha-ketoglutarate to succinate during TCA cycle. - Vitamin B2 is used as FAD in the TCA cycle, contributing to the oxidation and reduction reactions in energy metabolism. - Vitamin B3 exists as NAD in the TCA cycle, contributing to oxidation and reduction reactions in energy metabolism.

5. Vitamin B6, Folic Acid, Vitamin B12: Vascular and Brain Protection through Homocysteine Control - Homocysteine is a substance formed when methionine cannot be synthesized into cysteine, damaging blood vessel walls and threatening brain health. - Vitamin B6, folic acid, and vitamin B12 are involved in homocysteine metabolism, protecting blood vessels and the brain. - Co-administration of fermented garlic extract and vitamin B6, folic acid, and B12 showed improved enhancement of coronary atherosclerosis compared to individual intake*.

6. Molybdenum: Support for the Activation of Garlic Sulfur Compounds - Molybdenum is an antioxidant mineral needed for the activity of oxidative and reductive enzymes. - SAC is one of the sulfur compounds, and the activation of sulfur compounds depends on sulfite oxidase.

Selling Point

1. Enhancing SAC Absorption with Orally Dissolvable Film (ODF) - Oral dissolvables involve the direct absorption of functional ingredients into the bloodstream through the oral mucosa. - They bypass the digestive metabolism, resulting in minimal loss of functional ingredients and rapid absorption within the body, making them suitable for emergency medications such as angina treatments. - Oral mucosa has a permeability approximately 4,000 times greater than the epidermis, making it suitable for the application of water-soluble low molecular weight substances.

2. A Product Combining SAC and Vitamin B Complex with the Formula of Garlic Injection - Taking into account the typical prescription dosage of Fulsultiamine (commonly found in garlic injection), a blend was formulated. - The product contains 100mg of fermented garlic extract (SAC 1%), ensuring 1mg of SAC based on human application trials. - Research reports confirm SAC's benefits in anti-cancer, antioxidation, anti-inflammation, hypertension, and atherosclerosis improvement. - Research also reveals the mechanisms related to brain fatigue recovery supported by SAC (cortisol, dopamine, TGF-β). - It includes vitamin B1, B2, and B3 that support the TCA cycle in cellular respiration, helping the body derive energy. - Vitamin B6, folic acid, and B12 help regulate homocysteine levels, protecting blood vessels and the brain. - Molybdenum is included to activate garlic sulfur compounds.

3. Synergistic Blend to Enjoy All of SAC's Benefits from Fatigue Recovery to Vascular Health and Brain Protection - SAC, as a new active component in garlic, offers a wide range of health benefits based on anti-oxidation and anti-inflammation. - The product consists of eight ingredients to fully enjoy all the benefits of SAC, from fatigue recovery through nervous system support to vascular health and brain protection. - Ingredients include: SAC, Vitamin B1, Vitamin B2, Vitamin B3, Vitamin B6, Folic Acid, Vitamin B12, and Molybdenum.

4. Individual Packaging for Oxidation Prevention and Convenient Carrying and Consumption - Individual film packaging within the case helps prevent oxidation of functional ingredients and enhances portability and convenience. - When attached to the oral mucosa, the product offers a refreshing lemon flavor for improved ease of consumption. - If you used to receive "garlic injections" at the dermatologist's office and wish for a simple, single-dose solution, this product is designed for your convenience.

Those who want the convenience of carrying and consuming the "garlic injection" they used to receive at the dermatologist's office in a single dose Those who, despite all efforts, are plagued by chronic fatigue that doesn't seem to go away Those who haven't experienced the desired effects with conventional fatigue recovery ingredients Those who wish to intake both the Vitamin B complex and the effective components of garlic simultaneously Those who desire to experience SAC's outstanding antioxidant and anti-inflammatory effects Those who wish to experience SAC's benefits in fatigue recovery, vascular health, and brain protection