DR.ESTHER PERILLA FRUTESCENS FOCUS UP FOR EYESTRAIN

Daily Intake: 1 tablet (600mg)

※ % Nutritional Value: Percentages of the daily nutritional value

1. Eye Structure (Related to Focusing)
– Cornea: The primary refractive organ of the eye, similar to the lens of a camera.
– Ciliary Body (Ciliary Muscle): This structure secures and adjusts the lens, controlling its thickness to focus on objects at different distances. The contraction and relaxation of the ciliary muscle play a vital role in achieving precise focusing for near and distant objects.

2. Eye Fatigue
2-1. Causes of Eye Fatigue
– Eye fatigue typically arises from an overworked ciliary muscle due to near work and age-related diminished accommodative power. It can also result from dry environmental conditions, leading to dry eye discomfort, and excessive exposure to bright light.

2-2. Symptoms of Eye Fatigue
– Symptoms of eye fatigue include blurriness, tearing, redness, eye discomfort, stiffness, and a sensation of foreign objects. In severe cases, it can lead to pain, headaches, and dry eyes. Impaired eye function may result in decreased visual acuity, night blindness, and dry eye symptoms.

2-3. Modern Individuals Overexposed to Environments Posing Risks to Eye Health
– In 2021, the average weekly internet usage time for Korean youth was 24.9 hours for teenagers and 30.4 hours for those in their twenties (Source: 2022 Statistics from the Ministry of Gender Equality and Family).
– In 2021, the smartphone usage rate in Korea reached 97.5% for all age groups, with annual increases in usage rates. The primary purposes of smartphone use include communication with others, watching TV, and viewing videos, activities that require extended screen viewing (Source: KOSIS – National Statistics Portal, Korea Gallup Report).

2-4. Visual Display Terminals (VDT) Syndrome
– VDT syndrome refers to psychological and physical symptoms resulting from handling electronic devices like computers and mobile devices for extended periods.
– VDT syndrome is associated with eye fatigue, eye dryness, and accommodative fatigue caused by excessive use and prolonged exposure to screens.

3. Regulation of Eye Fatigue and Perilla Frutescens Extract
– Perilla frutescens extract is a traditional medicinal plant used in various Asian countries, such as Korea, China, and Japan, for treating symptoms like depression, anxiety, allergies, and colds.
– Luteolin glycosides in perilla frutescens extract contribute to reducing eye fatigue.
– Mechanism of action: ① NO/cGMP pathway: By increasing cGMP levels, it reduces calcium concentrations within smooth muscle cells, inducing relaxation of the ciliary smooth muscle.
② Antioxidant activity: Three antioxidant components within perilla frutescens extract inhibit the generation of reactive oxygen species, which induce oxidative stress.
(Among the three antioxidant components, Luteolin-7-O-β-D-diglucuronide (L7DG) has the highest concentration.)

1) Using individually approved Perilla frutescens extract recognized for its functionality by MFDS / L7DG content 22.3mg
– Consume 100% of the daily intake of Perilla frutescens extract with one tablet
– Perilla frutescens extract from domestically grown Perilla frutescens extract obtained through hot water extraction in Jeollanam-do
– Use Perilla frutescens extract concentrated by 5,000% (Extract only 11kg out of 550kg of fresh Perilla frutescens leaves => About 50 times (5,000%))
– Manage the content of index components (L7DG) consistently and at a high level through thorough verification and management from seeds to soil and moisture, using TCCS cultivation.

2) Main Ingredient: Perilla frutescens Extract for Digital Eye Health
– L7DG: A rutin glycoside contained in Perilla frutescens extract that relieves eye muscle fatigue.
– Confirmed improvement of eye health related to smartphone viewing in human application tests
: After viewing a smartphone up close, an improvement in eye fatigue and a decrease in the accommodative point due to the contraction of the ciliary muscle were observed.
: Significant decreases in the accommodative point and convergence point were confirmed.

3) Sub-Ingredients: Various plant-based ingredients blended for eye health management
– Berry Concentrate Powder*, Jujube Extract Powder, Cornus Fruit Extract Powder, Beta-Carotene Blend, Bilberry Fruit Extract Powder
(*Berry Concentrate Powder: Blueberry Juice, Aronia Juice, Cherry, Chinese Dogwood Fruit, Raspberry, Muscadine Grape, Blackberry)

4) Tablets with No Additives
– Free from carboxymethylcellulose, synthetic flavors, artificial coloring, and sweeteners
– Magnesium stearate, silicon dioxide, and hydroxypropyl methylcellulose are essential for refined production.

5) Convenient intake with one tablet per day and hygienic management with PTP packaging.

6) Produced under strict quality control at globally verified manufacturing facilities
– Kosmax Bio: GMP, ISO 9001, and FSSC 22000 certified

7) Ingredient blending expertise of Dr. LYUH ESTHER
– Dr. LYUH ESTHER: Preventive medicine doctor from Seoul National University College of Medicine, Family Medicine Specialist

Those who spend a lot of time working on a computer.
Those who have been exposed to computers and smartphones from a young age.
Those experiencing eye fatigue due to the use of digital devices.
Those who frequently engage in nighttime or extended driving.
Those who use electronic devices in low-light conditions.
Those who want to manage their eye fatigue and overall eye health.