| Ingredients & Contents |
Ginkgo leaf extract (USA), vitamin E mixed preparation (dl-α-tocopherol acetate, modified starch, dextrin, silicon dioxide), vitamin B6 hydrochloride, folic acid, crystalline cellulose, mixed lactose (lactose/USA, dextrin), dextrin, fermented black garlic (Netherlands), Centella Asiatica leaf extract powder [Centella extract (Centella/domestic), dextrin], seaweed calcium, silicon dioxide, magnesium stearate, hydroxypropylmethylcellulose, vitamin B12 mixed preparation (dextrin, trisodium citrate, citric acid, vitamin B12), glycerin, hawthorn extract powder, HK natto culture, hesperidin, boxthorn fruit extract
* Contains milk, soy |
| Main Ingredient |
1. Blood Circulation
- Blood circulation refers to the process where blood, pumped from the heart, carries oxygen and nutrients through the arteries and collects waste products via the lymphatic system, eventually returning through the veins.
- Arterial circulation-related diseases: cold hands and feet, limb numbness, arteriosclerosis, myocardial infarction, ischemic heart disease, cerebral hemorrhage.
-Venous circulation-related diseases: swollen legs, lower limb edema, leg numbness, cramps.
2. Two Key Elements of Blood Circulation
① Homeostasis of blood circulation: The human body forms blood clots by aggregating platelets in case of bleeding, and excessive clots are broken down by the fibrinolytic system to maintain homeostasis.
② Endothelium: The endothelial cells regulate blood flow and tension through various bioactive substances and are involved in platelet aggregation, clot formation, and clot dissolution.
3. Causes of Blood Circulation Disorders
(1) Excessive blood coagulation (excessive clotting)
- Overactivation of coagulation factors causes an increase in platelet aggregation and adhesion, narrowing the blood vessels and obstructing blood flow.
(2) Endothelial cell dysfunction
- Inflammation and oxidative stress can damage endothelial cells, leading to the accumulation of oxidized cholesterol at the damaged site, forming plaques and narrowing the vessels, similar to (1).
(3) Reduced vascular elasticity
- Decreased elasticity of blood vessels due to increased rigidity of the vessel wall and reduced smooth muscle cell tone.
4. Main Symptoms and Solutions for Blood Circulation Disorders
- Blood circulation disorders can be divided into ① arterial circulation problems and ② venous circulation problems.
- Causes of blood circulation disorders:
① Narrowing of blood vessels due to excessive blood clotting or other factors
② Problems in vascular health (elasticity, endothelial cell damage, valve permeability).
- ① Narrowing of blood vessels: Functional ingredients that help suppress excessive platelet aggregation, remove excess clots, and ensure smooth blood flow can be considered.
- ② Endothelial cell dysfunction: For cases where endothelial cells are damaged, antioxidant and anti-inflammatory nutrients or functional ingredients that help regulate homocysteine levels can be considered.
- Since blood circulation disorders can be classified into arterial and venous circulation issues, functional ingredients addressing each type can be considered.
① Ginkgo Biloba Extract: Blood Circulation Support Through Antioxidation, Antiplatelet, and Peripheral Vessel Dilation
- Functional Benefits: Ginkgo biloba extract may help improve memory and promote better circulation.
- Active Ingredients: Flavonoid glycosides and terpenoids in Ginkgo biloba extract:
1) Inhibition of platelet aggregation: Prevents excessive clot formation by suppressing platelet aggregation.
2) Peripheral vessel dilation: Expands peripheral blood vessels, improving inner ear circulation and potentially alleviating tinnitus.
3) Antioxidant effects: Protects blood vessels, heart, and brain from oxidative stress damage.
[Composition] Flavonoid glycosides 36mg per daily intake (2 tablets), maximum allowable concentration according to the Ministry of Food and Drug Safety.
- [Study] In vitro studies show that Ginkgo biloba extract inhibits platelet aggregation in plasma (PRP) differently from other flavonoids.
https://www.tandfonline.com/doi/abs/10.1080/09537109975933
Raw Material: USA, Flavonoid 24% purity
② Vitamin B6, Folic Acid: Homocysteine Regulation / Vitamin E: Protects Blood Vessels from Oxidative Stress, Prevents Endothelial Damage
- Homocysteine: A metabolite of the essential amino acid methionine, normally converted to cysteine or methionine at low levels in healthy individuals.
- Deficiency in Vitamin B6, Folic Acid, and Vitamin B12: Leads to oxidative stress that can directly damage artery walls, contributing to arteriosclerosis.
[Composition] Vitamin B6 100%, Folic Acid 100%, Vitamin B12 (as an excipient).
- [Clinical Trial] In patients with atherosclerosis, supplementation of aged black garlic (AGE) with Vitamin B6, B12, and folic acid significantly improved key markers compared to individual supplementation.
Source
Vitamin E: A potent antioxidant that inhibits oxidative stress, helping protect blood vessel endothelial cells.
Clinical Trial: α-Tocopherol suppressed reactive oxygen species release and lipid oxidation via protein kinase C inhibition.
https://www.sciencedirect.com/science/article/abs/pii/S0091743509003181
Raw Material: Vitamin B6 (Germany, DSM, NON-GMO)
Raw Material: Folic Acid (Switzerland, DSM)
Raw Material: Vitamin B9 (DSM)
Raw Material: Vitamin E (France, DSM)
③ Centella Asiatica Extract (100mg): Effect on Reducing Leg Swelling and Edema
- Function: Centella Asiatica extract is commonly used for improving venous circulation and reducing swelling, making it an important ingredient in formulations targeting leg edema.
- Active Ingredient: Triterpenes, the key active compound in Centella Asiatica, have been shown to help reduce leg swelling and improve capillary permeability.
- [Clinical Trials] A clinical trial on patients with venous hypertension showed significant improvement in capillary permeability and ankle edema after 1 month of supplementation with 120mg of triterpenes per day.
Source
- A follow-up study on the same group showed a reduction in leg edema and improvement in leg discomfort after 1 month of 180mg per day.
https://journals.sagepub.com/doi/abs/10.1177/000331970105202S11
Raw Material: Domestically sourced.
④ Black Garlic Extract (100mg): Antioxidant Protection for Blood Vessels via SAC
- Function: Black garlic extract, particularly its component S-allyl cysteine (SAC), is recognized for its potent antioxidant effects, which help protect blood vessels.
- Manufacturing: SAC 1% extract from Dutch black garlic, 120x concentrated (120kg of fresh garlic is used to obtain 1kg of extract), and halal-certified.
- Molecular Structure: SAC is a low molecular weight compound (162 m/z), making it easy for absorption through the oral mucosa, particularly in film dosage forms.
- [Clinical Trial] A 12-month study of 134 participants with vascular health issues showed significant improvements in capillary blood flow and vascular elasticity with 2400mg of black garlic extract per day.
https://onlinelibrary.wiley.com/doi/full/10.1111/iwj.13220
Raw Material: Dutch origin, SAC 1%, halal-certified.
⑤ Blood Circulation Supporting Ingredients (6 types)
- Vitamin B12 Blend: Essential for homocysteine metabolism and endothelial cell protection.
Raw Material: DSM, NON-GMO
- Hawthorn Extract: Widely recognized for its benefits in supporting blood circulation.
- Nattokinase: Derived from the Bacillus subtilis strain, nattokinase is known for its ability to dissolve blood clots and support circulation.
Raw Material: Domestically sourced, fibrinolytic activity of 14,000-22,000 units.
- Hesperidin: A flavonoid that helps reduce swelling and improve valve permeability, contributing to better circulation.
Raw Material: Chinese origin, purity >95%.
- Sophora Japonica Extract: Contains rutin, a compound that reduces leg swelling and has antioxidant properties to protect blood vessels.
Raw Material: Indian origin, sophoricoside 10%.
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| Selling Point |
① A product that addresses the causes of circulatory disorders, including platelet aggregation, endothelial damage, arterial circulation, and venous circulation all at once.
- Circulatory disorders require consideration of nutrients that assist in different types (arterial circulation, venous circulation) and causes.
- Key symptoms of arterial circulation include cold extremities, numbness in limbs, and arteriosclerosis. Key symptoms of venous circulation include leg swelling, lower limb edema, limb numbness, and cramps.
Flavonol glycosides in Ginkgo Leaf Extract help improve blood circulation through platelet aggregation inhibition and antioxidant effects (Flavonol glycosides 36mg, complies with KFDA regulations).
Combining 100% Vitamin B6 and 100% Vitamin B9 helps regulate homocysteine levels, protecting arteries from oxidative stress.
Incorporating 100% Vitamin E helps protect endothelial cells from oxidative stress, normalizing vascular elasticity and endothelial permeability.
② Including 100mg of 'Centella Asiatica Extract,' which showed improvement in leg swelling (venous circulation) in SCIE human trials.
- The main component of Centella Asiatica Extract, Triterpene, has been confirmed to improve leg swelling and microvascular permeability.
Human trials involving venous hypertension patients showed improvements in leg swelling and discomfort.
③ Combining 100mg of 'Black Garlic Extract' (SAC 1mg), which provides strong antioxidative effects through S-allyl-cysteine for vascular protection.
- SAC found in black garlic provides powerful antioxidative effects, protecting vascular endothelium and improving blood flow.
Human trials involving vascular patients showed improvements in vascular elasticity and microvascular blood flow.
④ Six blood circulation sub-ingredients
- A combination of six sub-ingredients known for their potential to support blood circulation, with high recognition and scientific backing.
- Essential nutrient 'Vitamin B12' for homocysteine metabolism.
- 'Nattokinase' for improved blood circulation through thrombolysis.
- 'Hesperidin' extensively researched for its role in reducing edema and improving capillary permeability.
- 'Rutin' in 'Scholar Tree Fruit Extract' is known for reducing leg swelling and providing antioxidative effects.
- 'Crataegus Oxyacantha Extract,' frequently included in formulations for improved blood circulation and cognition.
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