LYUH ESTHER SAC FERMENTED BLACK GARLIC DIRECT

1. SAC (S-Allyl-Cysteine)
- SAC is a water-soluble sulfur compound found in garlic extract during high-temperature aging. It has garnered attention as a new active ingredient in garlic.
- Garlic injection, used in dermatology for fatigue recovery, primarily contains Allicin (Allysin + Thiosin), but SAC has gained more attention due to superior research results and mechanisms compared to the older Allicin
- During the aging process of garlic extract, the Allin content decreases to 10% or less, while the SAC content increases by more than four times*1.
- Various mechanisms related to [antioxidant, anti-inflammatory, vascular diseases] improvement, as well as [fatigue recovery], have been confirmed through SCIE-grade papers.

2. Human Trials on SAC's Effects
① Antioxidant and Anti-inflammatory Activity: Antioxidant and Anti-inflammatory Activity: Removal of reactive oxygen species (ROS), reduction of lipid peroxidation, increase in GSH (glutathione) levels, activation of Nrf2 factor, reduction of cytokines.
② Fatigue Recovery (Korea FDA Biomarkers)
- [Blood] Promotes glucose metabolism in skeletal muscles, increases lactate dehydrogenase, reduces lactate concentration, has antioxidant and anti-inflammatory effects.
- [Muscles] Increases lactate dehydrogenase activity.
- [Brain] Reduces cortisol levels, prevents dopamine depletion, decreases TGF-β (transforming growth factor beta).
③ Vascular Health (Alleviating Hypertension and Coronary Artery Atherosclerosis), Anti-Cancer (Reducing Tumor Size in Colorectal Cancer), Weight Loss (Reducing Body Fat).

1. What is Garlic Injection?
- Garlic injection is a prescribed injection used for the purpose of fatigue recovery in dermatology. Its primary component is 'Fulsultiamine.'
- In the early 1990s, it was used in Japan for the purpose of enhancing the recovery and stamina of athletes *2. 
- Fulsultiamine is a chemically synthesized compound that increases the bioavailability of Allicin (Allysin + Thiosin) found in garlic.
- Inspired by the well-recognized and effective garlic injection, SAC and thiamine were blended as ingredients, replacing Allicin.

2. Why the Brain is Vital for Chronic Fatigue Recovery
- [Korea FDA] Chronic fatigue recovery is a state where fatigue persists for more than six months, even with rest, accompanied by a decrease in cognitive ability, sleep disorders, reduced concentration, and more.
- Among the [blood, muscle, and brain] biomarkers related to fatigue recovery, the brain is particularly important in chronic fatigue.
- According to the [North American Nursing Diagnosis Association], when defining fatigue as a "state characterized by overwhelming, sustained exhaustion not relieved by rest," it must be perceived by the 'brain.'

3. Basic Superhealth Effects of SAC (Anti-inflammatory, Antioxidant, Anti-cancer, and Vascular Health Improvement) + Fatigue Recovery Effect (Chronic Fatigue Recovery through Nervous System Support)
- SAC is a component whose content increases by more than 4 times during the fermentation of garlic extract, and various mechanisms related to fatigue recovery have been identified.
- [Antioxidant and Anti-inflammatory Mechanisms] *3
· Removal of Reactive Oxygen Species: Removal of hydrogen peroxide, superoxide anion, hydroxyl radical, peroxynitrite radical.
· Induction of Antioxidant Enzymes: Reduction of lipid peroxidation, increase in GSH levels.
· Activation of Nrf2 Factor: Increased expression of NAD and Nrf2 in the brain.
  *What is Nrf? Nrf regulates the basal and inducible expression of antioxidant and cellular protective genes as the guardian of redox homeostasis.
· Inhibition of Oxidative Promoting Enzymes: Inhibition of NOS, XO, NADPH, COX.
· Reduction of Cytokines: Decrease in IL-1, TNF-α.

- Fatigue Recovery ① [Blood] Mechanism
  · Glucose: Promotes glucose metabolism in skeletal muscles (increase in SDH activity, regulation of SOD activity) *4
  · Lactate: Reduction in lactate concentration, increase in lactate dehydrogenase activity *5

- Fatigue Recovery ② [Muscle] Mechanism
· LDH: Reduction in lactate concentration, increase in lactate dehydrogenase activity *6

- Fatigue Recovery ③ [Brain] Mechanism
· Corticosterone: Reduction in cortisol levels *7
· Dopamine: Prevention of dopamine depletion *8
· TGF-β: Reduction in transforming growth factor concentration*9
*What is TGF-β?: TGF-β is a transforming growth factor, and its increased concentration is known to increase feelings of fatigue in the brain and exacerbate depression.

4. Vitamin B1, Vitamin B2, Vitamin B3: Synergy in Fatigue Recovery through TCA Metabolism Support
- TCA metabolism is the process of cellular respiration where pyruvate, derived from glucose breakdown, is metabolized to produce energy within mitochondria.
- SAC promotes glucose metabolism by increasing SDH (succinate dehydrogenase) activity in the TCA metabolism process.
- Vitamin B1 helps convert alpha-ketoglutarate to succinate during TCA cycle.
- Vitamin B2 is used as FAD in the TCA cycle, contributing to the oxidation and reduction reactions in energy metabolism.
- Vitamin B3 exists as NAD in the TCA cycle, contributing to oxidation and reduction reactions in energy metabolism.

5. Vitamin B6, Folic Acid, Vitamin B12: Vascular and Brain Protection through Homocysteine Control
- Homocysteine is a substance formed when methionine cannot be synthesized into cysteine, damaging blood vessel walls and threatening brain health.
 - Vitamin B6, folic acid, and vitamin B12 are involved in homocysteine metabolism, protecting blood vessels and the brain.
- Co-administration of fermented garlic extract and vitamin B6, folic acid, and B12 showed improved enhancement of coronary atherosclerosis compared to individual intake *10

6. Molybdenum: Support for the Activation of Garlic Sulfur Compounds
- Molybdenum is an antioxidant mineral needed for the activity of oxidative and reductive enzymes.
- SAC is one of the sulfur compounds, and the activation of sulfur compounds depends on sulfite oxidase.
- Molybdenum is a key substance in the sulfate oxidase reaction and can enhance the detoxification ability of garlic sulfur compounds *11.

Selling Point

① Enhancing Absorption of SAC, the Key Ingredient for Chronic Fatigue Recovery, with Oral Dissolving Film (ODF)
- Oral dissolving means the functional ingredient is directly absorbed into the capillaries through the mucous membranes in the mouth.
- Since it bypasses digestion and metabolism, there is less loss of the functional ingredients, and the absorption speed in the body is faster, making it suitable for emergency medicines like angina treatment.
- Especially, the oral mucosa has about 4,000 times the permeability of the epidermis, making it suitable for applying water-soluble low-molecular substances.

② A Product with SAC and Vitamin B Complex Added to the Formula of 'Garlic Injection' for Fatigue Recovery
- The formula is blended considering the typical dosage of 50-100mg of Prurasilthiamine (garlic injection).
- Contains 100mg of fermented garlic extract (1% SAC), ensuring 1mg of SAC, the dose confirmed by human application tests.
  - Research reports confirm SAC’s effects in cancer prevention, antioxidant, anti-inflammatory, hypertension, and atherosclerosis improvement.
  - Research also confirms the neuro-supportive mechanisms of SAC related to brain fatigue recovery (cortisol, dopamine, TGF-β).
- Vitamin B1, B2, and B3 support the TCA cycle, which is the cell respiration process that provides energy to our body.
- Vitamin B6, folic acid, and B12 help control homocysteine levels to protect blood vessels and the brain.
- Molybdenum activates garlic sulfur compounds.

③ Synergistic Blend to Fully Benefit from SAC’s Effects on Fatigue Recovery, Vascular Health, and Brain Protection
- SAC, a new active ingredient in garlic, has been confirmed to have broad health benefits, primarily in antioxidant and anti-inflammatory properties.
- A blend of 8 ingredients to fully benefit from SAC’s advantages in fatigue recovery, vascular health, and brain protection:
  - SAC / Vitamin B1 / Vitamin B2 / Vitamin B3 / Vitamin B6 / Folic Acid / Vitamin B12 / Molybdenum

④ Preventing Oxidation of Functional Ingredients with Individual Packaging & Easy to Carry and Consume
- Individual film packaging inside the case helps prevent oxidation of the functional ingredients and enhances portability.
- The refreshing lemon scent improves the ease of consumption when attached to the oral mucosa.

- Those who want to easily carry and consume the 'garlic injection' they used to receive at the dermatologist with just one piece.
- For office workers struggling with chronic fatigue that never seems to go away despite rest.
- Those who have not seen results from typical fatigue recovery ingredients.
- Those who want to take both Vitamin B complex and the active ingredients of garlic at once.
- Those who want to experience SAC's super antioxidant and anti-inflammatory effects.
- Those who want to experience SAC’s effects on fatigue recovery, vascular health, and brain protection.