Spermidine Direct

Effect

- Helps slow down aging naturally

- Boosts energy and overall vitality

- Supports a healthy metabolism and weight

Net Contents

5.04 g (360 mg X 14 sheets)

Quantity per Carton

250

Ingredients & Contents  

Miricell Rice Germ Extract (China) [Dextrin, Rice Germ Extract 20%, Citric Acid], Pullulan, Japanese Knotweed Stem Extract (India) [Japanese Knotweed Stem Extract, Maltodextrin], Plum Flavor Powder, Luo Han Guo Extract Powder (China), Green Tea Extract, Plum Flavor, Gamma-Cyclodextrin, Herb Extract Powder, Cyclodextrin Syrup, Citric Acid, DL-Malic Acid, Grapefruit Flavor Powder, Vitamin C, Hydroxypropyl Methylcellulose, Glycerin, Pectin, Modified Starch, Natural Grapefruit Flavor, Polysorbate 80, MCT Powder, Vitamin E, Calcium Carboxymethylcellulose, Aspartame (contains phenylalanine), Yeast-Based Food, Indian Barberry Fruit Extract Powder, Sucralose, Yellow No. 5

* Contains Milk

Precautions for Consumption

- Store in a clean, cool place at room temperature, away from direct sunlight and high humidity

- Consume immediately after opening

- Due to the nature of the product, slight color changes, bubbles, cracks, breakage, or sticking may occur, but these do not affect product quality

- Individuals with specific conditions or allergies may experience hypersensitive reactions, so please check the ingredients before consuming

- Be careful when opening, as the packaging may cause injury

Intake Amount & Method

Place it on the roof of your mouth and let it slowly dissolve

Expiration Date 

24 months from the date of manufacture

Main Ingredient

① Spermidine: Life Extension Through Activation of Autophagy

- Background: While calorie restriction is the most reliable method for inducing autophagy, reducing daily caloric intake by 30% for life is not sustainable. As a result, scientists have searched for natural compounds with similar effects, and spermidine has emerged as the top candidate.

- Key Benefits: Spermidine-induced autophagy contributes to a wide range of anti-aging effects including DNA stabilization, prevention of stem cell exhaustion, and stimulation of immune cells.

- Mechanism of Action: Increases autophagy, promotes mitochondrial biogenesis, and supports epigenetic reprogramming

1) Spermidine directly induces autophagy and is endogenously synthesized from arginine, playing a mechanistically linked role

2) Acts as a substrate in the hypusination reaction, ultimately enhancing mitochondrial biogenesis

3) Functions as an intermediary influencer of various proteins and enzymes such as sirtuins, AMPK, and mTOR

② Resveratrol (5%): The Most Extensively Studied Phytochemical Calorie Restriction Mimetic

- A polyphenol extracted from grape skins or Japanese knotweed

- While known for its blood sugar-lowering and antidiabetic effects, it is now gaining attention as the most rigorously researched natural calorie restriction mimetic

- Key Benefits

1) Replicates the benefits of calorie restriction

2) Demonstrated lifespan extension in animal models

3) Proven effects on health improvement and disease prevention

- Mechanism of Action

1) Activates AMPK and inhibits mTOR (Calorie Restriction Mimetic)

2) Promotes autophagy

③ Green Tea Catechin (70%): The Phytochemical Most Similar to Rapamycin Among CR Mimetics

- Known for its functionality in weight management, antioxidant activity, and cholesterol support

- Rapamycin: A pharmaceutical known to induce autophagy via mTOR inhibition, primarily used as an anti-cancer drug

- Key Benefits

  Identified as the most similar natural compound to rapamycin among 800 phytochemicals through AI deep learning comparison

- Mechanism of Action

1) Activates AMPK and inhibits mTOR (Calorie Restriction Mimetic)

2) Functions as a rapamycin analog

3) Promotes autophagy

④ Berberine (5%): A Well-Studied Phytochemical Analog of the Pharmaceutical Metformin

- A compound derived from barberry, widely researched for its effects on energy metabolism and insulin regulation

- Metformin: A diabetes medication shown to improve insulin sensitivity, induce autophagy, and extend lifespan

- Key Benefits: Berberine has been directly compared to metformin in numerous studies

- Mechanism of Action

1) Activates AMPK and inhibits mTOR (Calorie Restriction Mimetic)

2) Functions as a metformin analog

3) Promotes autophagy

Selling Point

① Spermidine: Inducing lifespan extension through autophagy

- The most well-documented way to activate autophagy to date is through [caloric restriction mimetics], and this formula combines the four most evidence-based compounds currently recognized in scientific literature.

- Spermidine directly induces autophagy and has been shown in animal models to extend lifespan by 25%.

 • Aged individuals exhibit reduced expression of autophagy-related genes

 • Spermidine derived from wheat germ extract maximizes the benefits as a natural compound

 • Oral administration of spermidine in animal models activated autophagy and led to a 25% increase in lifespan

② Three highly substantiated caloric restriction mimetics: Resveratrol, Catechin, Berberine

- Caloric restriction is the only intervention proven to extend both healthspan and maximum lifespan in aging research; compounds mimicking these effects are under active study

- Resveratrol: The most extensively and rigorously studied phytochemical mimicking caloric restriction

- Green tea catechin: A natural analog of the pharmaceutical [Rapamycin], shown to induce autophagy via caloric restriction mimetic pathways

- Berberine: A natural analog of the pharmaceutical [Metformin], shown to induce autophagy through caloric restriction mimetic effects

Recommended Target

- Individuals over 50 who frequently experience fatigue

- Those looking for an anti-aging supplement to take alongside NMN

- Those who want to enhance the effects of intermittent fasting

- Those who prefer to take spermidine derived from natural, not synthetic, sources